Ontology highlight
ABSTRACT:
SUBMITTER: Chen BB
PROVIDER: S-EPMC3763433 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Chen B B BB Glasser J R JR Coon T A TA Mallampalli R K RK
Cell death & disease 20130808
Aurora B kinase is an integral regulator of cytokinesis, as it stabilizes the intercellular canal within the midbody to ensure proper chromosomal segregation during cell division. Here we identified that the ubiquitin E3 ligase complex SCF(FBXL2) mediates Aurora B ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis. Three molecular acceptor sites (K¹⁰², K¹⁰³ and K²⁰⁷) within Aurora B protein were identified as important sites for its ubiq ...[more]