Ontology highlight
ABSTRACT:
SUBMITTER: Schmeing TM
PROVIDER: S-EPMC3763470 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20091015 5953
The ribosome selects a correct transfer RNA (tRNA) for each amino acid added to the polypeptide chain, as directed by messenger RNA. Aminoacyl-tRNA is delivered to the ribosome by elongation factor Tu (EF-Tu), which hydrolyzes guanosine triphosphate (GTP) and releases tRNA in response to codon recognition. The signaling pathway that leads to GTP hydrolysis upon codon recognition is critical to accurate decoding. Here we present the crystal structure of the ribosome complexed with EF-Tu and amino ...[more]