Ontology highlight
ABSTRACT:
SUBMITTER: Kang HJ
PROVIDER: S-EPMC3763487 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Kang Hyo Jung HJ Adams David H DH Simen Arthur A Simen Birgitte B BB Rajkowska Grazyna G Stockmeier Craig A CA Overholser James C JC Meltzer Herbert Y HY Jurjus George J GJ Konick Lisa C LC Newton Samuel S SS Duman Ronald S RS
The Journal of neuroscience : the official journal of the Society for Neuroscience 20071101 48
Investigations of the molecular mechanisms underlying major depressive disorder (MDD) have been hampered by the complexity of brain tissue and sensitivity of gene expression profiling approaches. To address these issues, we used discrete microdissections of postmortem dorsolateral prefrontal cortex (DLPFC) (area 9) and an oligonucleotide (60mer) microarray hybridization procedure that increases sensitivity without RNA amplification. Mixed-effects statistical methods were used to rigorously contr ...[more]