Ontology highlight
ABSTRACT:
SUBMITTER: Laterreur N
PROVIDER: S-EPMC3763530 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Laterreur Nancy N Eschbach Sébastien H SH Lafontaine Daniel A DA Wellinger Raymund J RJ
Nucleic acids research 20130619 16
The stability of chromosome ends, the telomeres, is dependent on the ribonucleoprotein telomerase. In vitro, telomerase requires at least one RNA molecule and a reverse transcriptase-like protein. However, for telomere homeostasis in vivo, additional proteins are required. Telomerase RNAs of different species vary in size and sequence and only few features common to all telomerases are known. Here we show that stem-loop IVc of the Saccharomyces cerevisiae telomerase RNA contains a structural ele ...[more]