Ontology highlight
ABSTRACT:
SUBMITTER: Geißler V
PROVIDER: S-EPMC3763533 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Geißler Verena V Altmeyer Simone S Stein Benjamin B Uhlmann-Schiffler Heike H Stahl Hans H
Nucleic acids research 20130620 16
Non-sense-mediated mRNA decay (NMD) is a mechanism of translation-dependent mRNA surveillance in eukaryotes: it degrades mRNAs with premature termination codons (PTCs) and contributes to cellular homeostasis by downregulating a number of physiologically important mRNAs. In the NMD pathway, Upf proteins, a set of conserved factors of which Upf1 is the central regulator, recruit decay enzymes to promote RNA cleavage. In mammals, the degradation of PTC-containing mRNAs is triggered by the exon-junc ...[more]