Ontology highlight
ABSTRACT:
SUBMITTER: Benowitz NL
PROVIDER: S-EPMC3763712 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Benowitz Neal L NL Zhu Andy Z X AZ Tyndale Rachel F RF Dempsey Delia D Jacob Peyton P
Pharmacogenetics and genomics 20130301 3
<h4>Background</h4>Bupropion, an antidepressant and smoking cessation medication, is metabolized to hydroxybupropion (HB), an active metabolite, primarily by CYP2B6.<h4>Objectives</h4>To compare plasma concentrations of bupropion and metabolites at steady state in healthy volunteers with and without CYP2B6 genetic variants.<h4>Methods</h4>In a genotype-guided study of 42 healthy individuals, we measured the plasma and urine concentrations of bupropion and its metabolites, HB, threohydrobupropion ...[more]