Prognostic relevance of changes in exercise test variables in pulmonary arterial hypertension.

ABSTRACT:

Introduction

Exercise variables determined in patients with pulmonary arterial hypertension (PAH) at the time of diagnosis, predict survival. It is unknown whether upon treatment, subsequent changes in these exercise variables reflect improvements in survival. The aim of this study was to determine changes in exercise variables in PAH patients and to relate these changes to survival.

Methods

Baseline cardiopulmonary exercise test (CPET) variables and six-minute-walk-distance (6MWD) were available from 65 idiopathic PAH patients (50 females; mean age 45±2yrs). The same variables were determined after treatment (13months) in a sub group of 43 patients. To estimate the association between changes in exercise variables and changes in cardiac function, right-ventricle ejection fr

SUBMITTER: Groepenhoff H 

PROVIDER: S-EPMC3764059 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature