Dataset Information

Prenatal exposure to persistent organochlorines and childhood obesity in the US collaborative perinatal project.

ABSTRACT:

Background

In some previous studies, prenatal exposure to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p´-DDE), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) has been associated with higher body mass index (BMI) in children.

Objective

Our goal was to evaluate the association of maternal serum levels of ?-hexachlorocyclohexane (?-HCH), p,p´-DDE, dichlorodiphenyltrichloroethane (p,p´-DDT), dieldrin, heptachlor epoxide, HCB, trans-nonachlor, oxychlordane, and PCBs with offspring obesity during childhood.

Methods

The analysis was based on a subsample of 1,915 children followed until 7 years of age as part of the U.S. Collaborative Perinatal Project (CPP). The CPP enrolled pregnant women in 1959-1965; exposure levels were measured in third-trimester maternal serum that was collected before these organochlorines were banned in the United States. Childhood overweight and obesity were defined using age- and sex-specific cut points for BMI as recommended by the International Obesity Task Force.

Results

Adjusted results did not show clear evidence for an association between organochlorine exposure and obesity; however, a suggestive finding emerged for dieldrin. Compared with those in the lowest quintile (dieldrin, < 0.57 ?g/L), odds of obesity were 3.6 (95% CI: 1.3, 10.5) for the fourth and 2.3 (95% CI: 0.8, 7.1) for the highest quintile. Overweight and BMI were unrelated to organochlorine exposure.

Conclusions

In this population with relatively high levels of exposure to organochlorines, no clear associations with obesity or BMI emerged.

SUBMITTER: Cupul-Uicab LA

PROVIDER: S-EPMC3764072 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Publications

Prenatal exposure to persistent organochlorines and childhood obesity in the US collaborative perinatal project.

Cupul-Uicab Lea A LA Klebanoff Mark A MA Brock John W JW Longnecker Matthew P MP

Environmental health perspectives 20130625 9

<h4>Background</h4>In some previous studies, prenatal exposure to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p´-DDE), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) has been associated with higher body mass index (BMI) in children.<h4>Objective</h4>Our goal was to evaluate the association of maternal serum levels of β-hexachlorocyclohexane (β-HCH), p,p´-DDE, dichlorodiphenyltrichloroethane (p,p´-DDT), dieldrin, heptachlor epoxide, HCB, tran ...[more]

PMID: 23799652

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Dataset Information

Prenatal exposure to persistent organochlorines and childhood obesity in the US collaborative perinatal project.

Background

Objective

Methods

Results

Conclusions

Publications

Prenatal exposure to persistent organochlorines and childhood obesity in the US collaborative perinatal project.

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