Cell-type specific features of circular RNA expression.
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ABSTRACT:
SUBMITTER: Salzman J
PROVIDER: S-EPMC3764148 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Cell-type specific features of circular RNA expression.
Salzman Julia J Chen Raymond E RE Olsen Mari N MN Wang Peter L PL Brown Patrick O PO
PLoS genetics 20130905 9
Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using an improved computational approach for circular RNA identification, we found widespread circular RNA expression in Drosophila melanogaster and estimate that in humans, circular RNA may account for 1% as many molecules as poly(A) RNA. Analysis of data from the ENCODE consortium revealed that the repertoire of genes expressing circular RNA, t ...[more]
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