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Obesity and metabolic syndrome in circadian Clock mutant mice.

ABSTRACT: The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.

SUBMITTER: Turek FW

PROVIDER: S-EPMC3764501 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature

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Obesity and metabolic syndrome in circadian Clock mutant mice.

Turek Fred W FW Joshu Corinne C Kohsaka Akira A Lin Emily E Ivanova Ganka G McDearmon Erin E Laposky Aaron A Losee-Olson Sue S Easton Amy A Jensen Dalan R DR Eckel Robert H RH Takahashi Joseph S JS Bass Joseph J

Science (New York, N.Y.) 20050421 5724

The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was at ...[more]

PMID: 15845877

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Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.

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The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis.

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