Ontology highlight
ABSTRACT:
SUBMITTER: Kwun HJ
PROVIDER: S-EPMC3764649 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Kwun Hyun Jin HJ Shuda Masahiro M Feng Huichen H Camacho Carlos J CJ Moore Patrick S PS Chang Yuan Y
Cell host & microbe 20130801 2
Merkel cell polyomavirus (MCV) causes an aggressive human skin cancer, Merkel cell carcinoma, through expression of small T (sT) and large T (LT) viral oncoproteins. MCV sT is also required for efficient MCV DNA replication by the multifunctional MCV LT helicase protein. We find that LT is targeted for proteasomal degradation by the cellular SCF(Fbw7) E3 ligase, which can be inhibited by sT through its LT-stabilization domain (LSD). Consequently, sT also stabilizes cellular SCF(Fbw7) targets, in ...[more]