Ontology highlight
ABSTRACT:
SUBMITTER: Park YK
PROVIDER: S-EPMC3764836 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Park Young-Kwon YK Park Bongju B Lee Seongyeol S Choi Kang K Moon Yunwon Y Park Hyunsung H
The Journal of biological chemistry 20130730 36
Adipocyte hyperplasia and hypertrophy in obesity can lead to many changes in adipose tissue, such as hypoxia, metabolic dysregulation, and enhanced secretion of cytokines. In this study, hypoxia increased the expression of Wnt10b in both human and mouse adipogenic cells, but not in hypoxia-inducible factor (HIF)-2α-deficient adipogenic cells. Chromatin immunoprecipitation analysis revealed that HIF-2α, but not HIF-1α, bound to the Wnt10b enhancer region as well as upstream of the Wnt1 gene, whic ...[more]