A catalase promoter variant rs1001179 is associated with visual acuity but not with primary angle closure glaucoma in Saudi patients.

ABSTRACT:

Background

To Investigate whether the g.4760C>T polymorphism in the promoter region of the catalase gene (CAT) is a risk factor for primary angle closure glaucoma (PACG) in the Saudi population.

Methods

138 unrelated PACG patients and 403 unrelated control subjects from Saudi Arabia were genotyped for a single nucleotide polymorphism (SNP; rs1001179; g.4760C>T) utilizing Taq-Man(®) assay. The association between different genotypes and various clinical indices important for PACG was also investigated.

Results

The distribution of different genotypes was comparable between both study groups. The genotype "C/C" was predominant among cafses; 94 (68.1%) and controls; 289 (71.7%). Heterozygous genotype "C/T", was present in 41 (29.7%) of cases and 103 (25.6%) of controls, w

SUBMITTER: Abu-Amero KK 

PROVIDER: S-EPMC3765135 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature