Ontology highlight
ABSTRACT:
SUBMITTER: Furusawa J
PROVIDER: S-EPMC3765427 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Furusawa Jun-ichi J Moro Kazuyo K Motomura Yasutaka Y Okamoto Kazuo K Zhu Jinfang J Takayanagi Hiroshi H Kubo Masato M Koyasu Shigeo S
Journal of immunology (Baltimore, Md. : 1950) 20130712 4
Natural helper (NH) cells, a member of Lin(-)IL-2R(+)IL-7R(+)IL-25R(+)IL-33R(+)GATA3(+) group 2 innate lymphoid cell subset, are characterized by the expression of transcription factors GATA3 and RORα and production of large amounts of Th2 cytokines such as IL-5, IL-6, and IL-13 upon IL-33 stimulation or a combination of IL-2 and IL-25. We have studied the signal transduction pathways critical for the cytokine expression and development of NH cell. Either stimulation with IL-33 or a combination ...[more]