PKIS: computational identification of protein kinases for experimentally discovered protein phosphorylation sites.

ABSTRACT:

Background

Dynamic protein phosphorylation is an essential regulatory mechanism in various organisms. In this capacity, it is involved in a multitude of signal transduction pathways. Kinase-specific phosphorylation data lay the foundation for reconstruction of signal transduction networks. For this reason, precise annotation of phosphorylated proteins is the first step toward simulating cell signaling pathways. However, the vast majority of kinase-specific phosphorylation data remain undiscovered and existing experimental methods and computational phosphorylation site (P-site) prediction tools have various limitations with respect to addressing this problem.

Results

To address this issue, a novel protein kinase identification web server, PKIS, is here presented for the ident

SUBMITTER: Zou L 

PROVIDER: S-EPMC3765618 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature