A novel method to assess collagen architecture in skin.
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ABSTRACT:
SUBMITTER: Osman OS
PROVIDER: S-EPMC3765639 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
A novel method to assess collagen architecture in skin.
Osman Osman S OS Selway Joanne L JL Harikumar Parvathy E PE Stocker Claire J CJ Wargent Edward T ET Cawthorne Michael A MA Jassim Sabah S Langlands Kenneth K
BMC bioinformatics 20130826
<h4>Background</h4>Texture within biological specimens may reveal critical insights, while being very difficult to quantify. This is a particular problem in histological analysis. For example, cross-polar images of picrosirius stained skin reveal exquisite structure, allowing changes in the basketweave conformation of healthy collagen to be assessed. Existing techniques measure gross pathological changes, such as fibrosis, but are not sufficiently sensitive to detect more subtle and progressive ...[more]
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