Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC3766319 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Guo Yanxia Y Pino-Lagos Karina K Ahonen Cory A CA Bennett Kathy A KA Wang Jinshan J Napoli Joseph L JL Blomhoff Rune R Sockanathan Shanthini S Chandraratna Roshantha A RA Dmitrovsky Ethan E Turk Mary Jo MJ Noelle Randolph J RJ
Cancer research 20120817 20
While vitamin A has been implicated in host resistance to infectious disease, little is known about the role of vitamin A and its active metabolite, retinoic acid (RA) in host defenses against cancer. Here, we show that local RA production within the tumor microenvironment (TME) is increased up to 5-fold as compared with naïve surrounding tissue, with a commensurate increase in RA signaling to regionally infiltrating tumor-reactive T cells. Conditional disruption of RA signaling in CD8(+) T cell ...[more]