Ontology highlight
ABSTRACT:
SUBMITTER: Zhu H
PROVIDER: S-EPMC3766402 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Zhu Hongliang H Zhou Yuyi Y Castillo-González Claudia C Castillo-González Claudia C Lu Amber A Ge Chunxiao C Zhao Ying-Tao YT Duan Liusheng L Li Zhaohu Z Axtell Michael J MJ Wang Xiu-Jie XJ Zhang Xiuren X
Nature structural & molecular biology 20130811 9
MicroRNAs (miRNAs) originate from primary transcripts (pri-miRNAs) with characteristic stem-loop structures, and their accurate processing is required for the production of functional miRNAs. Here, using the pri-miR-166 family in Arabidopsis thaliana as a paradigm, we report the crucial role of pri-miRNA terminal loops in miRNA biogenesis. We found that multibranched terminal loops in pri-miR-166s substantially suppress miR-166 expression in vivo. Unlike canonical processing of pri-miRNAs, termi ...[more]