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Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.

ABSTRACT: Recent data suggest excess circulating aldosterone promotes cardiometabolic decline. Weight loss may lower aldosterone levels, but little longitudinal data is available in normotensive adults. We aimed to determine whether, independent of changes in sodium excretion, reductions in serum aldosterone are associated with favorable changes in obesity-related factors in normotensive overweight/obese young adults. We studied 285 overweight/obese young adult participants (body mass index ? 25 and<40 kg?m?², age 20-45 years) in a clinical trial examining the effects of a 1-year diet and physical activity intervention with or without sodium restriction on vascular health. Body weight, serum aldosterone, 24-h sodium and potassium excretion and obesity-related factors were measured at baseline, 6, 12 and 24 months. Weight loss was significant at 6 (7%), 12 (6%) and 24 months (4%; all P<0.0001). Decreases in aldosterone were associated with decreases in C-reactive protein, leptin, insulin, homeostasis assessment of insulin resistance, heart rate, tonic cardiac sympathovagal balance and increases in adiponectin (all P<0.05) in models adjusting for baseline age, sex, race, intervention arm, time since baseline, and sodium and potassium excretion. Weight loss and reductions in thigh intermuscular fat (intermuscular adipose tissue area; IMAT) were associated with decreases in aldosterone in the subgroup (n=98) with metabolic syndrome (MetS) at baseline (MetS × weight loss, P=0.04; MetS × change in IMAT, P=0.04). Favorable changes in obesity-related factors are associated with reductions in aldosterone in young adults with no risk factors besides excess weight, an important finding, given aldosterone's emergence as an important cardiometabolic risk factor.

SUBMITTER: Cooper JN

PROVIDER: S-EPMC3766434 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.

Cooper Jennifer N JN Fried Linda L Tepper Ping P Barinas-Mitchell Emma E Conroy Molly B MB Evans Rhobert W RW Mori Brooks Maria M Woodard Genevieve A GA Sutton-Tyrrell Kim K

Hypertension research : official journal of the Japanese Society of Hypertension 20130509 10

Recent data suggest excess circulating aldosterone promotes cardiometabolic decline. Weight loss may lower aldosterone levels, but little longitudinal data is available in normotensive adults. We aimed to determine whether, independent of changes in sodium excretion, reductions in serum aldosterone are associated with favorable changes in obesity-related factors in normotensive overweight/obese young adults. We studied 285 overweight/obese young adult participants (body mass index ≥ 25 and<40 kg ...[more]

PMID: 23657296

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Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.

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Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.

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