Ontology highlight
ABSTRACT:
SUBMITTER: Huttenhain R
PROVIDER: S-EPMC3766734 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Hüttenhain Ruth R Soste Martin M Selevsek Nathalie N Röst Hannes H Sethi Atul A Carapito Christine C Farrah Terry T Deutsch Eric W EW Kusebauch Ulrike U Moritz Robert L RL Niméus-Malmström Emma E Rinner Oliver O Aebersold Ruedi R
Science translational medicine 20120701 142
The rigorous testing of hypotheses on suitable sample cohorts is a major limitation in translational research. This is particularly the case for the validation of protein biomarkers; the lack of accurate, reproducible, and sensitive assays for most proteins has precluded the systematic assessment of hundreds of potential marker proteins described in the literature. Here, we describe a high-throughput method for the development and refinement of selected reaction monitoring (SRM) assays for human ...[more]