Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer.
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ABSTRACT:
SUBMITTER: Reese AC
PROVIDER: S-EPMC3766748 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
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Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer.
Reese Adam C AC Hardin Jill J Cheng Iona I Casey Graham G Witte John S JS
Pharmaceuticals (Basel, Switzerland) 20101001 10
Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depe ...[more]
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