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Separacenes A-D, novel polyene polyols from the marine actinomycete, Streptomyces sp.

ABSTRACT: Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.

SUBMITTER: Bae M

PROVIDER: S-EPMC3766871 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Separacenes A-D, novel polyene polyols from the marine actinomycete, Streptomyces sp.

Bae Munhyung M Kim Heegyu H Shin Yoonho Y Kim Byung Yong BY Lee Sang Kook SK Oh Ki-Bong KB Shin Jongheon J Oh Dong-Chan DC

Marine drugs 20130813 8

Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety ...[more]

PMID: 23945600

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