Ontology highlight
ABSTRACT:
SUBMITTER: Zhao G
PROVIDER: S-EPMC3767303 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Zhao Gaoping G Moore Daniel J DJ Kim James I JI Lee Kang Mi KM O'Connor Matthew R MR Duff Patrick E PE Yang Maozhu M Lei Ji J Markmann James F JF Deng Shaoping S
Science translational medicine 20110601 87
The senescent immune system responds poorly to new stimuli; thymic involution, accumulation of memory cells against other specificities, and general refractoriness to antigen signaling all may contribute to poor resistance to infection. These same changes may pose a significant clinical barrier to organ transplantation, as transplantation tolerance requires thymic participation and integrated, tolerance-promoting responses to novel antigens. We found that after the age of 12 months, mice became ...[more]