Ontology highlight
ABSTRACT:
SUBMITTER: Mennella V
PROVIDER: S-EPMC3767400 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Mennella V V Keszthelyi B B McDonald K L KL Chhun B B Kan F F Rogers G C GC Huang B B Agard D A DA
Nature cell biology 20121021 11
As the main microtubule-organizing centre in animal cells, the centrosome has a fundamental role in cell function. Surrounding the centrioles, the pericentriolar material (PCM) provides a dynamic platform for nucleating microtubules. Although the importance of the PCM is established, its amorphous electron-dense nature has made it refractory to structural investigation. By using SIM and STORM subdiffraction-resolution microscopies to visualize proteins critical for centrosome maturation, we demo ...[more]