Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.
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ABSTRACT:
SUBMITTER: Yanes RE
PROVIDER: S-EPMC3767416 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.
Yanes Rolando E RE Tarn Derrick D Hwang Angela A AA Ferris Daniel P DP Sherman Sean P SP Thomas Courtney R CR Lu Jie J Pyle April D AD Zink Jeffrey I JI Tamanoi Fuyuhiko F
Small (Weinheim an der Bergstrasse, Germany) 20121114 5
The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing. ...[more]
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