Ontology highlight
ABSTRACT:
SUBMITTER: Younan ND
PROVIDER: S-EPMC3767752 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Younan Nadine D ND Sarell Claire J CJ Davies Paul P Brown David R DR Viles John H JH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130118 5
There is now strong evidence to show that the presence of the cellular prion protein (PrP(C)) mediates amyloid-β (Aβ) neurotoxicity in Alzheimer's disease (AD). Here, we probe the molecular details of the interaction between PrP(C) and Aβ and discover that substoichiometric amounts of PrP(C), as little as 1/20, relative to Aβ will strongly inhibit amyloid fibril formation. This effect is specific to the unstructured N-terminal domain of PrP(C). Electron microscopy indicates PrP(C) is able to tra ...[more]