A modeling framework for deriving the structural and functional architecture of a short-term memory microcircuit.
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ABSTRACT:
SUBMITTER: Fisher D
PROVIDER: S-EPMC3768012 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
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A modeling framework for deriving the structural and functional architecture of a short-term memory microcircuit.
Fisher Dimitry D Olasagasti Itsaso I Tank David W DW Aksay Emre R F ER Goldman Mark S MS
Neuron 20130901 5
Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typical studies that construct a phenomenological model and test whether it reproduces select aspects of neuronal data, we directly fit the synaptic connectivity of an oculomotor memory c ...[more]
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