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Nickel-catalyzed Suzuki-Miyaura couplings in green solvents.

ABSTRACT: The nickel-catalyzed Suzuki-Miyaura coupling of aryl halides and phenol-derived substrates with aryl boronic acids using green solvents, such as 2-Me-THF and tert-amyl alcohol, is reported. This methodology employs the commercially available and air-stable precatalyst, NiCl2(PCy3)2, and gives biaryl products in synthetically useful to excellent yields. Using this protocol, bis(heterocyclic) frameworks can be assembled efficiently.

SUBMITTER: Ramgren SD

PROVIDER: S-EPMC3768281 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Nickel-catalyzed Suzuki-Miyaura couplings in green solvents.

Ramgren Stephen D SD Hie Liana L Ye Yuxuan Y Garg Neil K NK

Organic letters 20130723 15

The nickel-catalyzed Suzuki-Miyaura coupling of aryl halides and phenol-derived substrates with aryl boronic acids using green solvents, such as 2-Me-THF and tert-amyl alcohol, is reported. This methodology employs the commercially available and air-stable precatalyst, NiCl2(PCy3)2, and gives biaryl products in synthetically useful to excellent yields. Using this protocol, bis(heterocyclic) frameworks can be assembled efficiently. ...[more]

PMID: 23879392

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