Ontology highlight
ABSTRACT:
SUBMITTER: Stoddard CD
PROVIDER: S-EPMC3769107 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Stoddard Colby D CD Widmann Jeremy J Trausch Jeremiah J JJ Marcano-Velázquez Joan G JG Knight Rob R Batey Robert T RT
Journal of molecular biology 20130226 10
Direct sensing of intracellular metabolite concentrations by riboswitch RNAs provides an economical and rapid means to maintain metabolic homeostasis. Since many organisms employ the same class of riboswitch to control different genes or transcription units, it is likely that functional variation exists in riboswitches such that activity is tuned to meet cellular needs. Using a bioinformatic approach, we have identified a region of the purine riboswitch aptamer domain that displays conservation ...[more]