Comprehensive assessment and network analysis of the emerging genetic susceptibility landscape of prostate cancer.

ABSTRACT:

Background

Recent advances in high-throughput genotyping have made possible identification of genetic variants associated with increased risk of developing prostate cancer using genome-wide associations studies (GWAS). However, the broader context in which the identified genetic variants operate is poorly understood. Here we present a comprehensive assessment, network, and pathway analysis of the emerging genetic susceptibility landscape of prostate cancer.

Methods

We created a comprehensive catalog of genetic variants and associated genes by mining published reports and accompanying websites hosting supplementary data on GWAS. We then performed network and pathway analysis using single nucleotide polymorphism (SNP)-containing genes to identify gene regulatory networks and p

SUBMITTER: Hicks C 

PROVIDER: S-EPMC3769142 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature