Gray matter is targeted in first-attack multiple sclerosis.
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ABSTRACT:
SUBMITTER: Schutzer SE
PROVIDER: S-EPMC3769274 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Gray matter is targeted in first-attack multiple sclerosis.
Schutzer Steven E SE Angel Thomas E TE Liu Tao T Schepmoes Athena A AA Xie Fang F Bergquist Jonas J Vécsei László L Zadori Denes D Camp David G DG Holland Bart K BK Smith Richard D RD Coyle Patricia K PK
PloS one 20130910 9
The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain unknown. Some imaging studies suggest gray rather than white matter may be involved early, and some postulate this may be predictive of developing MS. Other imaging studies are in conflict. To determine if there was objective molecular evidence of gray matter involvement in early MS we used high-resolution mass spectrometry to identify protein ...[more]
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