Ontology highlight
ABSTRACT:
SUBMITTER: Robbins CS
PROVIDER: S-EPMC3769444 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Robbins Clinton S CS Hilgendorf Ingo I Weber Georg F GF Theurl Igor I Iwamoto Yoshiko Y Figueiredo Jose-Luiz JL Gorbatov Rostic R Sukhova Galina K GK Gerhardt Louisa M S LM Smyth David D Zavitz Caleb C J CC Shikatani Eric A EA Parsons Michael M van Rooijen Nico N Lin Herbert Y HY Husain Mansoor M Libby Peter P Nahrendorf Matthias M Weissleder Ralph R Swirski Filip K FK
Nature medicine 20130811 9
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall. The observation that circulating monocytes give rise to lesional macrophages has reinforced the concept that monocyte infiltration dictates macrophage buildup. Recent work has indicated, however, that macrophage accumulation does not depend on monocyte recruitment in some inflammatory contexts. We therefore revisited the mechanism underlying macrophage accumulation in ...[more]