Ontology highlight
ABSTRACT:
SUBMITTER: Oh C
PROVIDER: S-EPMC3769649 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Scientific reports 20130101
Ubiquitin is involved in almost every cellular process, and it is also known to be a stress-inducible protein. Based on previous reports that many types of cancer display an elevated level of ubiquitin, we hypothesized that this increased amount of ubiquitin is essential for the growth of cancer cells and that, consequently, the downregulation of ubiquitin may be a potential anti-cancer treatment. We first found that the level of ubiquitin can be effectively downregulated via knockdown of a poly ...[more]