Ontology highlight
ABSTRACT:
SUBMITTER: Jones BL
PROVIDER: S-EPMC3769926 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Jones Bryony L BL Raga Tamiru O TO Liebert Anke A Zmarz Pawel P Bekele Endashaw E Danielsen E Thomas ET Olsen Anders Krüger AK Bradman Neil N Troelsen Jesper T JT Swallow Dallas M DM
American journal of human genetics 20130829 3
The persistent expression of lactase into adulthood in humans is a recent genetic adaptation that allows the consumption of milk from other mammals after weaning. In Europe, a single allele (-13910(∗)T, rs4988235) in an upstream region that acts as an enhancer to the expression of the lactase gene LCT is responsible for lactase persistence and appears to have been under strong directional selection in the last 5,000 years, evidenced by the widespread occurrence of this allele on an extended hapl ...[more]