Ontology highlight
ABSTRACT:
SUBMITTER: Vincent T
PROVIDER: S-EPMC3769970 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Vincent Theresa T Neve Etienne P A EP Johnson Jill R JR Kukalev Alexander A Rojo Federico F Albanell Joan J Pietras Kristian K Virtanen Ismo I Philipson Lennart L Leopold Philip L PL Crystal Ronald G RG de Herreros Antonio Garcia AG Moustakas Aristidis A Pettersson Ralf F RF Fuxe Jonas J
Nature cell biology 20090713 8
Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, such as Ras and Wnt, to induce EMT, but the molecular mechanisms are not clear. Here, we report that SMAD3 and SMAD4 interact and form a complex with SNAIL1, a transcriptional repressor and promoter of EMT. The SNAIL1-SMAD3/4 complex was targeted to the gene promoters of CAR, a ti ...[more]