Ontology highlight
ABSTRACT:
SUBMITTER: Gillespie CF
PROVIDER: S-EPMC3770127 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Gillespie Charles F CF Almli Lynn M LM Smith Alicia K AK Bradley Bekh B Kerley Kimberly K Crain Daniel F DF Mercer Kristina B KB Weiss Tamara T Phifer Justine J Tang Yilang Y Cubells Joseph F JF Binder Elisabeth B EB Conneely Karen N KN Ressler Kerry J KJ
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20130315 3
A non-synonymous, single nucleotide polymorphism (SNP) in the gene coding for steroid 5-α-reductase type 2 (SRD5A2) is associated with reduced conversion of testosterone to dihydrotestosterone (DHT). Because SRD5A2 participates in the regulation of testosterone and cortisol metabolism, hormones shown to be dysregulated in patients with PTSD, we examined whether the V89L variant (rs523349) influences risk for post-traumatic stress disorder (PTSD). Study participants (N = 1,443) were traumatized A ...[more]