Ontology highlight
ABSTRACT:
SUBMITTER: Isom DG
PROVIDER: S-EPMC3770139 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Molecular cell 20130815 4
In response to environmental stress, cells often generate pH signals that serve to protect vital cellular components and reprogram gene expression for survival. A major barrier to our understanding of this process has been the identification of signaling proteins that detect changes in intracellular pH. To identify candidate pH sensors, we developed a computer algorithm that searches proteins for networks of proton-binding sidechains. This analysis indicates that Gα subunits, the principal trans ...[more]