APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.

ABSTRACT:

Objective

We aimed to examine the association of APOE ε genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds.

Methods

We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n = 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. When necessary, authors were contacted to provide effect estimates for the meta-analysis.

Results

APOE ε4 carrier status and APOE ε44 genotype were associated with increasing white matter hyperintensity burden (sample size-weighted z score meta-analysis [meta]-p = 0.0034 and 0.0030) and pres

SUBMITTER: Schilling S 

PROVIDER: S-EPMC3770168 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature