Dataset Information

APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.

ABSTRACT:

Objective

We aimed to examine the association of APOE ? genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds.

Methods

We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n = 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. When necessary, authors were contacted to provide effect estimates for the meta-analysis.

Results

APOE ?4 carrier status and APOE ?44 genotype were associated with increasing white matter hyperintensity burden (sample size-weighted z score meta-analysis [meta]-p = 0.0034 and 0.0030) and presence of cerebral microbleeds (meta odds ratio [OR] = 1.24, 95% confidence interval [CI] [1.07, 1.43], p = 0.004, and 1.87 [1.26, 2.78], p = 0.002), especially lobar. APOE ?2 carrier status was associated with increasing white matter hyperintensity load (z score meta-p = 0.00053) and risk of brain infarct (meta OR = 1.41[1.09, 1.81], p = 0.008).

Conclusions

APOE ?4 and APOE ?2 were associated with increasing burden in MRI markers for both hemorrhagic and ischemic CVD. While the association of APOE ?4 with an increased burden of CVD could be partly contributing to the relationship between APOE ?4 and AD, APOE ?2 was associated with MRI markers of CVD in the opposite direction compared to AD.

SUBMITTER: Schilling S

PROVIDER: S-EPMC3770168 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Publications

APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.

Schilling Sabrina S DeStefano Anita L AL Sachdev Perminder S PS Choi Seung Hoan SH Mather Karen A KA DeCarli Charles D CD Wen Wei W Høgh Peter P Raz Naftali N Au Rhoda R Beiser Alexa A Wolf Philip A PA Romero José Rafael JR Zhu Yi-Cheng YC Lunetta Kathryn L KL Farrer Lindsay L Dufouil Carole C Kuller Lewis H LH Mazoyer Bernard B Seshadri Sudha S Tzourio Christophe C Debette Stéphanie S

Neurology 20130701 3

<h4>Objective</h4>We aimed to examine the association of APOE ε genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds.<h4>Methods</h4>We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n = 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. ...[more]

PMID: 23858411

Similar Datasets

Project description:ObjectiveTo clarify associations of fish consumption and long chain omega 3 fatty acids with risk of cerebrovascular disease for primary and secondary prevention.DesignSystematic review and meta-analysis.Data sourcesStudies published before September 2012 identified through electronic searches using Medline, Embase, BIOSIS, and Science Citation Index databases.Eligibility criteriaProspective cohort studies and randomised controlled trials reporting on associations of fish consumption and long chain omega 3 fatty acids (based on dietary self report), omega 3 fatty acids biomarkers, or supplementations with cerebrovascular disease (defined as any fatal or non-fatal ischaemic stroke, haemorrhagic stroke, cerebrovascular accident, or transient ischaemic attack). Both primary and secondary prevention studies (comprising participants with or without cardiovascular disease at baseline) were eligible.Results26 prospective cohort studies and 12 randomised controlled trials with aggregate data on 794,000 non-overlapping people and 34,817 cerebrovascular outcomes were included. In cohort studies comparing categories of fish intake the pooled relative risk for cerebrovascular disease for 2-4 servings a week versus ≤ 1 servings a week was 0.94 (95% confidence intervals 0.90 to 0.98) and for ≥ 5 servings a week versus 1 serving a week was 0.88 (0.81 to 0.96). The relative risk for cerebrovascular disease comparing the top thirds of baseline long chain omega 3 fatty acids with the bottom thirds for circulating biomarkers was 1.04 (0.90 to 1.20) and for dietary exposures was 0.90 (0.80 to 1.01). In the randomised controlled trials the relative risk for cerebrovascular disease in the long chain omega 3 supplement compared with the control group in primary prevention trials was 0.98 (0.89 to 1.08) and in secondary prevention trials was 1.17 (0.99 to 1.38). For fish or omega 3 fatty acids the estimates for ischaemic and haemorrhagic cerebrovascular events were broadly similar. Evidence was lacking of heterogeneity and publication bias across studies or within subgroups.ConclusionsAvailable observational data indicate moderate, inverse associations of fish consumption and long chain omega 3 fatty acids with cerebrovascular risk. Long chain omega 3 fatty acids measured as circulating biomarkers in observational studies or supplements in primary and secondary prevention trials were not associated with cerebrovascular disease. The beneficial effect of fish intake on cerebrovascular risk is likely to be mediated through the interplay of a wide range of nutrients abundant in fish.

Dataset Information

APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.

Objective

Methods

Results

Conclusions

Publications

APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.

Similar Datasets

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