Ontology highlight
ABSTRACT:
SUBMITTER: Stillman DJ
PROVIDER: S-EPMC3771362 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Trends in biochemical sciences 20130716 9
The chromatin structure at a promoter can define how a gene is regulated. Studies of two yeast genes expressed in the G1 phase of the cell cycle, HO and CLN2, have provided important paradigms for transcriptional regulation. Although the SBF (Swi4/Swi6 box factor) transcription factor activates both genes, the chromatin landscapes that regulate SBF binding are different. Specifically, the CLN2 promoter is constitutively available for SBF binding, whereas HO has a complex two-step promoter in whi ...[more]