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Predictors of visual response to intravitreal bevacizumab for treatment of neovascular age-related macular degeneration.


ABSTRACT: Purpose. To identify the predictors of visual response to the bevacizumab treatment of neovascular age-related macular degeneration (AMD). Design. A cohort study within the Neovascular AMD Treatment Trial Using Bevacizumab (NATTB). Methods. This was a multicenter trial including 144 participants from the NATTB study. Visual outcomes measured by change in visual acuity (VA) score, proportion gaining ?15 letters, and change in central retinal thickness (CRT) were compared among groups according to the baseline, demographic, and ocular characteristics and genotypes. Results. Mean change in the VA score was 9.2 ± 2.3 SD letters with a total of 46 participants (31.9%) gaining ?15 letters. Change in median CRT was -81.5? ? m. Younger age, lower baseline VA score, shorter duration of neovascular AMD, and TT genotype in rs10490924 were significantly associated with greater VA score improvement (P = 0.028, P < 0.001, P = 0.02, and P = 0.039, resp.). Lower baseline VA score and TT genotype in rs10490924 were significantly associated with a higher likelihood of gaining ?15 letters (P = 0.028, and P = 0.021, resp.). Conclusions. Baseline VA and genotype of rs10490924 were both important predictors for visual response to bevacizumab at 6 months. This trial is registered with the Registration no. NCT01306591.

SUBMITTER: Fang K 

PROVIDER: S-EPMC3771417 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Predictors of visual response to intravitreal bevacizumab for treatment of neovascular age-related macular degeneration.

Fang Kai K   Tian Jun J   Qing Xueying X   Li Shuai S   Hou Jing J   Li Juan J   Yu Wenzhen W   Chen Dafang D   Hu Yonghua Y   Li Xiaoxin X  

Journal of ophthalmology 20130828


Purpose. To identify the predictors of visual response to the bevacizumab treatment of neovascular age-related macular degeneration (AMD). Design. A cohort study within the Neovascular AMD Treatment Trial Using Bevacizumab (NATTB). Methods. This was a multicenter trial including 144 participants from the NATTB study. Visual outcomes measured by change in visual acuity (VA) score, proportion gaining ≥15 letters, and change in central retinal thickness (CRT) were compared among groups according to  ...[more]

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