Sulfonylurea receptor 1 expression in human cerebral infarcts.
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ABSTRACT:
SUBMITTER: Mehta RI
PROVIDER: S-EPMC3771575 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Sulfonylurea receptor 1 expression in human cerebral infarcts.
Mehta Rupal I RI Ivanova Svetlana S Tosun Cigdem C Castellani Rudy J RJ Gerzanich Volodymyr V Simard J Marc JM
Journal of neuropathology and experimental neurology 20130901 9
In animal models of stroke, sulfonylurea receptor 1 (Sur1), a member of the adenosine triphosphate binding cassette transporter gene family, is transcriptionally upregulated in neural and vascular cells in which it plays a leading role in edema formation and necrotic cell death. To date, expression of Sur1 in the brains of humans with cerebral infarcts has not been systematically evaluated. We examined Sur1 expression in postmortem specimens obtained from 13 patients within the first 31 days aft ...[more]
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