Ontology highlight
ABSTRACT:
SUBMITTER: Tsay JJ
PROVIDER: S-EPMC3771678 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Tsay Junchieh J JJ Tchou-Wong Kam-Meng KM Greenberg Alissa K AK Pass Harvey H Rom William N WN
Anticancer research 20130401 4
The leading cause of lung cancer is exposure to cigarette smoke and other environmental pollutants, which include formaldehyde, acrolein, benzene, dioxin, and polycyclic aromatic hydrocarbons (PAHs). PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis. In this review article we summarize the current u ...[more]