Ontology highlight
ABSTRACT:
SUBMITTER: Bahal R
PROVIDER: S-EPMC3771998 | biostudies-literature | 2013 Apr-Jun
REPOSITORIES: biostudies-literature
Bahal Raman R McNeer Nicole Ali NA Ly Danith H DH Saltzman W Mark WM Glazer Peter M PM
Artificial DNA, PNA & XNA 20130401 2
The development of a new class of peptide nucleic acids (PNAs), i.e., gamma PNAs (γPNAs), creates the need for a general and effective method for its delivery into cells for regulating gene expression in mammalian cells. Here we report the antisense activity of a recently developed hydrophilic and biocompatible diethylene glycol (miniPEG)-based gamma peptide nucleic acid called MPγPNAs via its delivery by poly(lactide-co-glycolide) (PLGA)-based nanoparticle system. We show that MPγPNA oligomers ...[more]