Ontology highlight
ABSTRACT:
SUBMITTER: Elkhaled A
PROVIDER: S-EPMC3772177 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Elkhaled Adam A Jalbert Llewellyn E LE Phillips Joanna J JJ Yoshihara Hikari A I HAI Parvataneni Rupa R Srinivasan Radhika R Bourne Gabriela G Berger Mitchel S MS Chang Susan M SM Cha Soonmee S Nelson Sarah J SJ
Science translational medicine 20120101 116
Recent studies have indicated that a significant survival advantage is conferred to patients with gliomas whose lesions harbor mutations in the genes isocitrate dehydrogenase 1 and 2 (IDH1/2). IDH1/2 mutations result in aberrant enzymatic production of the potential oncometabolite D-2-hydroxyglutarate (2HG). Here, we report on the ex vivo detection of 2HG in IDH1-mutated tissue samples from patients with recurrent low-grade gliomas using the nuclear magnetic resonance technique of proton high-re ...[more]