Ontology highlight
ABSTRACT:
SUBMITTER: Barneaud-Rocca D
PROVIDER: S-EPMC3772184 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Barneaud-Rocca Damien D Etchebest Catherine C Guizouarn Hélène H
The Journal of biological chemistry 20130711 37
The anion exchanger 1 (AE1), a member of bicarbonate transporter family SLC4, mediates an electroneutral chloride/bicarbonate exchange in physiological conditions. However, some point mutations in AE1 membrane-spanning domain convert the electroneutral anion exchanger into a Na(+) and K(+) conductance or induce a cation leak in a still functional anion exchanger. The molecular determinants that govern ion movement through this transporter are still unknown. The present study was intended to iden ...[more]