Ontology highlight
ABSTRACT:
SUBMITTER: Zbytek B
PROVIDER: S-EPMC3772912 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Zbytek Blazej B Peacock Danielle L DL Seagroves Tiffany N TN Slominski Andrzej A
Dermato-endocrinology 20130401 2
Hypoxia-inducible factor-1α (HIF-1α) is a highly oxygen sensitive bHLH protein that is part of the heterodimeric HIF-1 transcription factor. Under hypoxic stress, HIF-1 activity is induced to control expression of multiple downstream target genes, including vascular endothelial growth factor (VEGF). The normal epidermis exists in a constant mild hypoxic microenvironment and constitutively expresses HIF-1α and HIF-2α. Expression of HIF-1α and/or HIF-2α has been suggested to correlate with the inc ...[more]