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Catching HIV 'in the act' with 3D electron microscopy.

ABSTRACT: The development of a safe, effective vaccine to prevent HIV infection is a key step for controlling the disease on a global scale. However, many aspects of HIV biology make vaccine design problematic, including the sequence diversity and structural variability of the surface envelope glycoproteins and the poor accessibility of neutralization-sensitive epitopes on the virus. In this review, we discuss recent progress in understanding HIV in a structural context using emerging tools in 3D electron microscopy, and outline how some of these advances could be important for a better understanding of mechanisms of viral entry and for vaccine design.

SUBMITTER: Earl LA

PROVIDER: S-EPMC3773172 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Catching HIV 'in the act' with 3D electron microscopy.

Earl Lesley A LA Lifson Jeffrey D JD Subramaniam Sriram S

Trends in microbiology 20130711 8

The development of a safe, effective vaccine to prevent HIV infection is a key step for controlling the disease on a global scale. However, many aspects of HIV biology make vaccine design problematic, including the sequence diversity and structural variability of the surface envelope glycoproteins and the poor accessibility of neutralization-sensitive epitopes on the virus. In this review, we discuss recent progress in understanding HIV in a structural context using emerging tools in 3D electron ...[more]

PMID: 23850373

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