Ontology highlight
ABSTRACT:
SUBMITTER: Elliott MR
PROVIDER: S-EPMC3773546 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Elliott Michael R MR Zheng Shuqiu S Park Daeho D Woodson Robin I RI Reardon Michael A MA Juncadella Ignacio J IJ Kinchen Jason M JM Zhang Jun J Lysiak Jeffrey J JJ Ravichandran Kodi S KS
Nature 20100901 7313
Apoptosis and the subsequent clearance of dying cells occurs throughout development and adult life in many tissues. Failure to promptly clear apoptotic cells has been linked to many diseases. ELMO1 is an evolutionarily conserved cytoplasmic engulfment protein that functions downstream of the phosphatidylserine receptor BAI1, and, along with DOCK1 and the GTPase RAC1, promotes internalization of the dying cells. Here we report the generation of ELMO1-deficient mice, which we found to be unexpecte ...[more]