Ontology highlight
ABSTRACT:
SUBMITTER: Minami T
PROVIDER: S-EPMC3773623 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Minami Toshiyuki T Kijima Takashi T Kohmo Satoshi S Arase Hisashi H Otani Yasushi Y Nagatomo Izumi I Takahashi Ryo R Miyake Kotaro K Higashiguchi Masayoshi M Morimura Osamu O Ihara Shoichi S Tsujino Kazuyuki K Hirata Haruhiko H Inoue Koji K Takeda Yoshito Y Kida Hiroshi H Tachibana Isao I Kumanogoh Atsushi A
Scientific reports 20130101
Small-cell lung cancer (SCLC) easily recurs with a multidrug resistant phenotype. However, standard therapeutic strategies for relapsed SCLC remain unestablished. We found that human epidermal growth factor receptor 2 (HER2) is not only expressed in pretreated human SCLC specimens, but is also upregulated when HER2-positive SCLC cells acquire chemoresistance. Trastuzumab induced differential levels of antibody-dependent cell-mediated cytotoxicity (ADCC) to HER2-positive SCLC cells. Furthermore, ...[more]