Inferior frontal cortex modulation with an acute dose of heroin during cognitive control.

ABSTRACT: Impairments in inhibitory control and in stimulus-driven attention are hallmarks of drug addiction and are associated with decreased activation in the right inferior frontal gyrus (IFG). Although previous studies indicate that the response inhibition function is impaired in abstinent heroin dependents, and that this is mediated by reduced IFG activity, it remains completely unknown whether and how an acute dose of heroin modulates IFG activity during cognitive control in heroin-dependent patients. This study investigates the acute effects of heroin administration on IFG activity during response inhibition and stimulus-driven attention in heroin-dependent patients. Using a cross-over, double-blind, placebo-controlled design, saline and heroin were administered to 26 heroin-dependent patient

SUBMITTER: Schmidt A 

PROVIDER: S-EPMC3773673 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature